# Helicase Venture

Helicase Venture is a Venture Capital based in Boston, United States.

## Overview

- **Organization type:** Venture Capital
- **Headquarters:** Boston, United States
- **Region:** North America
- **Address:** 1 Beacon Street, 15th Floor, Boston, MA 02108, United States
- **Founded:** 2018
- **Assets under management:** Undisclosed
- **Website:** www.helicaseventure.com
- **LinkedIn:** https://www.linkedin.com/company/helicase-venture

## Regulatory record

- **CRD number:** 297812
- **Registration status:** Registered
- **Reports private funds:** Yes
- **IAPD record:** https://adviserinfo.sec.gov/firm/summary/297812

## About

Helicase Venture is an early-stage venture firm focused on investing in innovative life sciences and Bio-IT (engineering health / AI companies). The firm invests in and supports innovative companies to reach their full potential, working with early-stage companies to unlock their potential and achieve breakthroughs in science that will have a meaningful impact on patient care. Investments are in early-stage, seed and Series A opportunities, typically committing between $1-5M at initial investment.

## Sectors

- Healthcare Services
- Digital Health
- Industrial Tech
- Energy Transition & Renewables

## People

- Richard Tsai — Managing Partner and Co-founder
- John Lee — Director
- Joy Lee — Partner

## Questions

### How does Helicase Venture source proprietary deal flow?

Helicase sources through its membership in the Biotechnology Innovation Organization (BIO) investor network, which provides access to vetted therapeutic and life-science startups emerging from US research hubs. Its Boston location at 1 Beacon Street places it within direct reach of Harvard and MIT spinouts. The firm's relationship with Hi-Clearance Inc. also creates a reverse-sourcing channel: Asian medical distributors identify unmet clinical needs that inform US scouting priorities.

### What is Helicase Venture's relationship with Hi-Clearance Inc.?

Hi-Clearance Inc. is a Taiwanese medical distribution company chaired by John Lee, who also serves as Director at Helicase. The two entities share leadership and strategic alignment: Helicase's early-stage investments in therapeutics and devices gain a potential commercial partner in Hi-Clearance, which distributes medical products throughout Taiwan's hospital systems. This creates an integrated pipeline from US FDA approval to Asian market access.

### Which sectors does Helicase Venture focus on?

Helicase concentrates on healthcare services and digital health, with additional exposure to industrial technology and the energy transition. Its strategy emphasizes early-stage companies that can benefit from cross-border scaling between US innovation centers and Asian commercial networks. The firm does not publicly disclose explicit sector exclusions, but its portfolio and affiliated operations center on regulated industries where distribution partnerships create durable advantages.

## Related profiles

- [Helical Capital Partners](https://altss.com/profile/helical-capital-partners)
- [Heligan Investments](https://altss.com/profile/heligan-investments)

---

Last updated: 2026-08-11T15:06:57.816Z

Canonical page: https://altss.com/profile/helicase-venture

Maintained by Altss — https://altss.com — methodology: https://altss.com/methodology