# J. David Gladstone Institutes

J. David Gladstone Institutes is an Endowment / Foundation based in San Francisco, United States.

## Overview

- **Organization type:** Endowment / Foundation
- **Headquarters:** San Francisco, United States
- **Region:** North America
- **Address:** 1650 Owens Street, San Francisco, CA 94158, United States
- **Founded:** 1979
- **Assets under management:** Undisclosed
- **Website:** gladstone.org
- **LinkedIn:** https://www.linkedin.com/company/gladstoneinstitutes

## Regulatory record

- **Reports private funds:** No

## About

J. David Gladstone established these independent institutes in 1979, channeling wealth from his real estate operations into a San Francisco research center. The organization operates as a charitable biomedical foundation, not a single-family office, with a full-time president, Deepak Srivastava, directing scientific strategy. An academic affiliation with the University of California, San Francisco gives the labs access to joint faculty, but Gladstone retains its own governance and a separate endowment. Strategy blends direct translational research with venture-style placement of its intellectual property. The institutes' scientists work across cardiovascular, viral, and neurological disease, an asset-class mix that spans early-stage drug discovery, lab spinouts, and fund commitments. A co-investment venture with Dolby Family Ventures, the Cure Network Dolby Acceleration Partners, targets neurodegeneration therapies. The board includes Nicholas J. Simon, a senior managing director at Blackstone Life Sciences, linking the non-profit to commercial drug-development capital. The physical footprint is concentrated at the Owens Street headquarters in Mission Bay, while collaborations extend to UC Berkeley, LBNL, and UC Davis through the Bay Area Postdoc Coalition. The base of 188 in estimated assets (Altss estimate) supports a lean team with eight investigators holding National Academy of Medicine membership. Trustee William S. Price, III, a TPG Capital co-founder, and board member Li Lu of Himalaya Capital bring deep allocator networks to the table. An associated vehicle, the Gladstone Foundation, handles aligned philanthropic grants. The institutes' intellectual property portfolio functions as a separate value store whose realized proceeds recycle into research. Most endowed research foundations operate as grant-making pass-throughs. Gladstone instead runs its own laboratories, hires its own faculty, and monetizes discoveries directly — an operating-company posture inside a non-profit wrapper. This structure gives it both the tax-advantaged horizon of a perpetual endowment and the execution tempo of a preclinical biotech portfolio.

## Sectors

- Healthcare Services

## People

- Deepak Srivastava — President
- William S. Price, III — Trustee
- Nicholas J. Simon — Trustee
- Li Lu — Foundation Board Member

## Questions

### How is Gladstone structured in relation to UCSF?

Gladstone is an independent, non-profit biomedical research organization with an academic affiliation agreement with UCSF. Faculty hold joint appointments, giving them access to university resources, but Gladstone controls its own governance, endowment, and labs. The president, Deepak Srivastava, reports to Gladstone's board of trustees, not the UC system.

### How does Gladstone commercialize its research?

Gladstone maintains its own intellectual property portfolio and can spin out companies or license discoveries directly. It also participates in structured co-investment vehicles, such as the Cure Network Dolby Acceleration Partners, a neurodegeneration-focused joint venture with Dolby Family Ventures. These structures allow the institutes to capture commercial upside from lab-stage breakthroughs.

### What is the Cure Network Dolby Acceleration Partners?

It is a co-investment venture between the Gladstone Institutes and Dolby Family Ventures, formed to accelerate cures for neurodegenerative diseases (per Altss research). The partnership pairs Gladstone's academic discovery engine with Dolby's venture capital deployment, creating a direct translational path from institute labs to funded startups.

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Last updated: 2026-06-03T20:00:00.000Z

Canonical page: https://altss.com/profile/j-david-gladstone-institutes

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