# Main Sequence Ventures

Main Sequence Ventures is a Venture Capital based in Sydney, Australia.

## Overview

- **Organization type:** Venture Capital
- **Headquarters:** Sydney, Australia
- **Region:** Oceania
- **Address:** Sydney, NSW, Australia
- **Founded:** 2017
- **Assets under management:** AUD 1,000M (Altss estimate)
- **Website:** mseq.vc
- **LinkedIn:** https://www.linkedin.com/company/mainsequence

## Regulatory record

- **Reports private funds:** No

## About

We work with inventors who are building something hard from their unique expertise in science. These inventors are building the industries that will thrive for the decades to come. We have a unique working model to accelerate a company's pathway to scale.

## Sectors

- Deep Tech
- SpaceTech
- ClimateTech
- Industrial Tech
- AgriTech & FoodTech
- AI/ML
- Healthcare Services
- Energy Transition & Renewables

## Offices

- Canberra, Australia
- Melbourne, Australia

## People

- Gabrielle Munzer — Partner
- Martin Duursma — Partner
- Mike Zimmerman — Partner

## Questions

### Who runs investment decisions at Main Sequence Ventures?

The partnership committee including Mike Zimmerman, Martin Duursma, and Gabrielle Munzer makes investment decisions, with final sign-off distributed across the GP team rather than concentrated in a single CIO. The firm also relies on a network of CSIRO scientists who provide pre-diligence technical assessments that influence whether a deal reaches the full partnership review stage.

### How does Main Sequence source its proprietary deal flow?

The firm's structural advantage is its embedded relationship with CSIRO, which gives it early visibility into publicly funded deep-tech research across Australia. Scientists and postdoctoral teams working inside CSIRO's labs often approach the firm before incorporating a separate legal entity, creating a sourcing pipeline that is difficult for external VCs to replicate. The firm also runs a creator-community program that introduces university spinout founders to its thematic objectives.

### What investment stages does Main Sequence typically target?

The firm covers pre-seed through Series B, with initial checks that scale from AUD 250,000 for pre-company formation science projects up to AUD 15 million for expansion rounds. It reserves material follow-on capital to support portfolio companies into international Series C rounds, often syndicating with US and European deep-tech funds at that stage.

### Which sectors does Main Sequence explicitly avoid?

The firm avoids SaaS businesses without a defensible scientific moat and has publicly stated it does not invest in enterprise-software companies that lack a hardware, biological, or physical-chemistry component (per AFR, 2021). Consumer-internet and fintech-lending models also fall outside its three named thematic streams.

### How is Main Sequence related to CSIRO?

Main Sequence was launched in 2017 with CSIRO as its founding limited partner and retains a first-look agreement on research emanating from CSIRO's labs. CSIRO does not control the investment committee, but its scientists participate in technical due-diligence reviews, and the firm's Canberra office is co-located with CSIRO's major research facilities. The relationship functions as a sourcing mechanism, not a captive funding mandate.

### Does Main Sequence participate in fund commitments or only direct deals?

Main Sequence deploys capital exclusively through direct equity investments into operating companies. It is not a fund-of-funds and does not allocate to external managers. On occasion, the firm structures co-investment alongside its own primary commitment, particularly when a syndicate requires a follow-on vehicle architecture, but it has never acted as a passive LP in another venture firm.

## Related profiles

- [Mainsail Partners](https://altss.com/profile/mainsail-partners)
- [Mainspring Capital Partners](https://altss.com/profile/mainspring-capital-partners)

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Last updated: 2026-06-03T20:00:00.000Z

Canonical page: https://altss.com/profile/main-sequence-ventures

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