# Medical Excellence Capital

Medical Excellence Capital is a Private Equity based in Nissequogue, United States.

## Overview

- **Organization type:** Private Equity
- **Headquarters:** Nissequogue, United States
- **Region:** North America
- **Address:** Nissequogue, NY, United States
- **Founded:** 2020
- **Assets under management:** Undisclosed
- **Website:** medexcelcap.com
- **LinkedIn:** https://www.linkedin.com/company/medexcelcap

## Regulatory record

- **CRD number:** 318278
- **SEC file number:** 802-123112
- **Registration status:** ACTIVE
- **Latest Form ADV filing:** 2026-03-06T06:00:00.000Z
- **Reports private funds:** Yes
- **Private funds reported:** 0
- **IAPD record:** https://adviserinfo.sec.gov/firm/summary/318278

## About

MEC is an early-stage life science venture fund that combines accomplished investment professionals and operators with a proprietary national medical network platform to create the most unique venture firm in life sciences. MEC deploys precision capital to nurture and advance the precision health innovations that solve the biggest, most complex medical problems.

## Sectors

- Digital Health
- AI/ML
- Genomics & Gene Therapy
- Cell Therapy
- Diagnostics
- Drug Discovery & Development
- Precision Medicine
- Regenerative Medicine
- Synthetic Biology

## People

- John Prufeta — Chief Executive Officer and Managing Partner
- Eric Heil — Managing Partner
- Kim Kamdar — Managing Partner
- Brian Halak — Managing Partner
- Joni Mancini — Managing Partner
- Max Colbert — Vice President
- Victoria Lewis — Vice President
- Tess Marvin — Associate
- Olga Prufeta — Limited Partner Liaison
- John P. Hornbostel — Counsel

## Questions

### Who runs investment decisions at Medical Excellence Capital?

John Prufeta, the founder and CEO, leads the firm alongside four other Managing Partners: Eric Heil, Kim Kamdar, Brian Halak, and Joni Mancini. The partnership blends operational health advisory experience with deep venture capital track records — Heil, Kamdar, and Halak all previously served as partners at Domain Associates, a life sciences venture fund with over $2.5 billion in managed capital.

### How does Medical Excellence Capital source proprietary deal flow?

The firm relies on the Medical Excellence Group, a private global health advisory chaired by Prufeta with offices in New York, Moscow, London, and Shanghai. This clinical network gives the venture fund direct lines to academic medical centers and practicing physicians who surface assets and validate therapeutic hypotheses before a formal financing process begins. MEC also creates companies internally — ProJenX, an ALS company, was co-created in partnership with Project ALS.

### Does Medical Excellence Capital focus on therapeutics, devices, or diagnostics?

MEC is stage-agnostic within early-stage life sciences but concentrates heavily on therapeutics and enabling platform technologies. The active portfolio includes cell therapy (Aspen Neuroscience), small-molecule neurodegeneration (ProJenX), AI-driven rare disease discovery (Nobias Therapeutics), synthetic biology for stem cell engineering (GC Therapeutics), and next-generation diagnostics (Truvian Sciences, Pleno). Gene therapy and protein degradation (Avilar Therapeutics) also feature.

### How is Medical Excellence Capital related to Domain Associates?

Three of MEC’s managing partners — Eric Heil, Kim Kamdar, and Brian Halak — built their venture careers at Domain Associates, a life sciences fund where Kamdar and Halak remain partners managing existing Domain funds. MEC is an independent firm founded by John Prufeta in 2020; the Domain alumni joined to provide investment expertise, but MEC is not a spinout, successor, or affiliate of Domain.

### What is Medical Excellence Capital’s relationship with the Medical Excellence Group and the Medical Excellence Foundation?

John Prufeta co-founded the Medical Excellence Group in 2007 and chairs it; the firm operates as a global private health advisory with offices across four cities. The Medical Excellence Foundation is a separate 501(c)(3) that provides research grants to academic medical centers. MEC, the venture fund, was launched later and uses the advisory network’s clinical reach for deal sourcing and due-diligence, but the three entities are legally distinct.

## Related profiles

- [Medical College of VA Foundation](https://altss.com/profile/medical-college-of-va-foundation)
- [Medical Incubator Japan](https://altss.com/profile/medical-incubator-japan)

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Last updated: 2026-06-03T20:00:00.000Z

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