# Penn Medicine

Penn Medicine is an Academic Health System based in Philadelphia, United States.

## Overview

- **Organization type:** Academic Health System
- **Headquarters:** Philadelphia, United States
- **Region:** North America
- **Address:** Philadelphia, PA, United States
- **Founded:** 1993
- **Assets under management:** $5.1B annual research spend (per Penn Medicine, 2025)
- **Website:** pennmedicine.org
- **LinkedIn:** https://www.linkedin.com/company/university-of-pennsylvania-health-system

## Regulatory record

- **Reports private funds:** No

## About

Penn Medicine is a healthcare institution founded in 2001 in Philadelphia, Pennsylvania. It specializes in urology, providing treatment for various urologic conditions. The institution is staffed by a team of urology professionals.

## Sectors

- Digital Health
- Healthcare Services
- Life Sciences
- Medical Devices
- Pharmaceuticals

## Offices

- Shanghai, China

## People

- Dr. Kevin B. Mahoney — CEO, University of Pennsylvania Health System
- Dr. J. Larry Jameson — Dean, Perelman School of Medicine

## Questions

### Who leads investment decisions at Penn Medicine?

Investment decisions are not centralized under a single CIO; the University of Pennsylvania's endowment is managed by the Penn Investment Office, while clinical and research capital allocation is directed by CEO Kevin Mahoney and Dean Jameson. Technology transfer is run by the Penn Center for Innovation.

### Does Penn Medicine act as a venture capital fund?

No. Penn Medicine operates as an academic medical center, not a fund. It does invest in its own spinouts through the Penn Center for Innovation, but does not manage a dedicated venture fund for external LPs. The institution's $10B+ endowment is invested by the University of Pennsylvania across public equities, private equity, and real assets.

### How does Penn Medicine commercialize its research?

Through the Penn Center for Innovation, which handles patenting, licensing, and startup creation. Notable examples include Spark Therapeutics (acquired by Roche for $4.3B in 2019) and gene-editing tools licensed to companies like Editas Medicine. The institution shares revenue with inventors.

### What is the relationship between Penn Medicine and the University of Pennsylvania's endowment?

The $10B+ endowment is managed by the separate Penn Investment Office. Penn Medicine does not directly allocate the endowment; its revenue comes from clinical care, grants, and philanthropy. The endowment supports the institution through payout distributions.

### What investment stages does Penn Medicine typically target through its commercialization efforts?

Penn Medicine's tech transfer focuses on early-stage spinouts (pre-seed to Series A) in life sciences and devices. It also participates in federal grants (NIH SBIR/STTR) and collaborates with external VCs to fund later-stage trials.

## Related profiles

- [American International Group](https://altss.com/profile/american-international-group)
- [Muggle Ventures](https://altss.com/profile/muggle-ventures)

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Last updated: 2026-06-03T20:00:00.000Z

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