# Praxis Precision Medicines

Praxis Precision Medicines is an Asset Manager based in Boston, United States.

## Overview

- **Organization type:** Asset Manager
- **Headquarters:** Boston, United States
- **Region:** North America
- **Address:** Boston, MA, United States
- **Founded:** 2015
- **Assets under management:** Undisclosed
- **Website:** praxismedicines.com
- **LinkedIn:** https://www.linkedin.com/company/praxis-precision-medicines-inc

## Regulatory record

- **Reports private funds:** No

## About

Praxis Precision Medicines was founded in 2015 by David Goldstein, a geneticist at Columbia University who built one of the earliest large-scale epilepsy sequencing programs, and Kirill Martemyanov, a neuroscientist whose work decoded the protein complexes behind neuronal signaling. The company's origin is inseparable from its method: Goldstein's lab identified rare genetic mutations that cause devastating brain disorders, and Martemyanov's lab mapped how those mutations physically break the circuits. That pairing of human genetics and structural biology defined Praxis from day one and continues to shape its pipeline. The firm's strategy is a clinical-stage, precision-medicine approach to central nervous system diseases. Its pipeline covers epilepsy (PRAX-628, a next-generation sodium channel blocker), essential tremor (ulixacaltamide, a T-type calcium channel modulator), and major depressive disorder (PRAX-114, a GABA-A receptor positive allosteric modulator). Praxis advances these programs through conventional FDA trial phases, funded by the public markets and earlier venture rounds from investors including Vida Ventures, Novo Holdings, and Blackstone Life Sciences. Structural hallmarks include a preference for wholly owned programs and a focus on targets validated by human genetic evidence, which is meant to raise the probability of trial success. Praxis became a public company in October 2020, listing on Nasdaq under the ticker PRAX with a $191 million IPO (per Renaissance Capital, 2020). The firm does not disclose a total headcount but operates a lean, discovery-through-development model typical of mid-stage biotechs. Its most consequential recent operational event was May 2022: Praxis announced a strategic reorganization that halved its workforce and narrowed its pipeline to three lead programs after its PRAX-114 major depressive disorder trial failed a Phase 2/3 study (per Fierce Biotech, May 2022). The restructuring also saw Marcio Souza, the former chief development officer, succeed the founding CEO. The company maintains its headquarters in Boston, Massachusetts. What distinguishes Praxis structurally is its extreme, explicit reliance on human genetics as the primary scaffolding for drug discovery — a model more commonly associated with Regeneron or Alnylam. Unlike platform companies that test compounds across many diseases, Praxis starts with a specific patient mutation, works backward to the disrupted protein complex, and designs a molecule to fit. That architecture makes every pipeline asset a bet on a discrete genetic hypothesis, which concentrates risk but, when validated, produces unusually clear narratives for regulators and payers.

## Sectors

- Digital Health
- Healthcare Services

## People

- Marcio Souza — Chief Executive Officer
- David Goldstein — Co-Founder
- Kirill Martemyanov — Co-Founder

## Questions

### What is Praxis's core drug-discovery thesis?

Praxis builds each drug program around a specific human genetic mutation linked to a CNS disorder, then designs small molecules to correct the downstream protein dysfunction. This genetic-insight-first model aims to reduce clinical-trial failure rates by validating the biological target in actual patients before entering the clinic.

### What investment stages or fund commitments does Praxis engage in?

None. Praxis is an operating biotech company, not an asset manager or fund investor. It does not make LP commitments to other funds, nor does it participate in direct co-investment structures typical of family offices. Its capital allocation is entirely internal R&D spending.

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Last updated: 2026-08-11T02:43:31.692Z

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