# Signet Healthcare Partners

Signet Healthcare Partners is a Private Equity based in New York, United States.

## Overview

- **Organization type:** Private Equity
- **Headquarters:** New York, United States
- **Region:** North America
- **Address:** Carnegie Hall Tower, 152 West 57th Street, 59th Fl, New York, NY 10019, United States
- **Founded:** 1998
- **Assets under management:** $100M - $250M (Altss estimate)
- **Website:** www.signethealthcarepartners.com
- **LinkedIn:** https://www.linkedin.com/company/signet-healthcare-partners

## Regulatory record

- **Reports private funds:** No

## About

Signet Healthcare Partners is a diversified healthcare investor that leads investments in expansion stage companies in specialty pharmaceuticals, medical devices, and pharma services. The firm invests globally, with approximately 20% of its funds committed to European and Asian entities. Signet Healthcare Partners has made 60 investments and has 16 portfolio exits.

## Sectors

- Pharmaceuticals
- Medical Devices
- Diagnostics
- Healthcare Services

## People

- James Gale — Founding Partner & Managing Director
- Ashley Friedman — Managing Director
- Nikhil Puri — Managing Director

## Questions

### Who makes investment decisions at Signet Healthcare Partners?

The Fund V team is led by three senior investment professionals: Founding Partner James Gale and Managing Directors Ashley Friedman and Nikhil Puri. They are supported by a network of venture partners and operating advisors, including former senior executives from Pfizer, Teva, and Johnson & Johnson. Investment decisions are made collectively at the partnership level, with board seats taken actively post-close.

### How does Signet Healthcare Partners source deals?

Sourcing relies on the team's 25-year network in healthcare, with a dedicated Business Development Officer, Vladimir Walko, who has more than 25 years of experience across pharmaceutical outsourcing and cell and gene therapy services. The firm also works with a network of operating partners and advisors who bring direct industry relationships. Signet leads rounds and builds syndicates when necessary, which contributes to proprietary flow.

### What is the typical check size, and does Signet co-invest alongside its LPs?

Signet's typical investment is $10 million to $50 million per portfolio company. The firm states that larger investments are available via co-investments. It takes significant minority or majority equity positions and prefers to act as a lead investor, building syndicates around its own commitments rather than passively following other sponsors.

### Which geographies does Signet cover?

The firm invests primarily in North America and Europe but has a history of investing in other geographies, usually with a local partner. Board seats are held across portfolio companies in the US, Canada (e.g., Knight Therapeutics, TSX: GUD), and Europe (e.g., NorthX Biologics AB in Sweden, Curida Group in Norway).

## Related profiles

- [Signet Financial Management](https://altss.com/profile/signet-financial-management)
- [Signia Ventures](https://altss.com/profile/signia-ventures)

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Last updated: 2026-06-03T20:00:00.000Z

Canonical page: https://altss.com/profile/signet-healthcare-partners

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