Reaction

Reaction splits portfolio management across two fund teams. Enrico Carbone and Singari Seshadri serve as General Partners for W250 Venture, the firm's first fund. Charles Froland, Mike Dorsey, and Managing Partner Dan Matthies lead Catalyst Fund. All five listed investment principals are sourced directly from the firm's own team page, with no external senior hires disclosed. An advisory board chaired by Carlos Moreira provides strategic guidance across both vehicles.

Reaction sources nearly all of its portfolio from the Stanford University ecosystem, where its founding team met and where Fund I is named after a Stanford classroom ("W250"). The firm draws from Stanford's climate labs and health-tech research groups. Additionally, Reaction publishes its own original research — including the Green Inflation and Impact Currency frameworks — which functions as inbound marketing to mission-aligned founders before formal fundraising processes begin.

Reaction invests directly in early-stage companies across four categories: climate tech, health tech, enterprise and consumer tech, and edtech. There is no evidence in the firm's published materials of fund-of-fund commitments, GP stakes, or secondary investments. The firm operates exclusively as a direct venture investor from its two funds.

Reaction has co-invested alongside external syndicates in rounds such as Splight's $12 million raise in July 2024, but does not publicly detail its co-investment partners. The firm's advisory board spans the US, UAE, Portugal, and Switzerland, suggesting an informal network for follow-on capital. No formal co-investment vehicle or club is disclosed on its site.

W250 Venture was Reaction's first fund and pursues a broad mandate across health technology, climate innovation, and enterprise tech. The Catalyst Fund, managed by Charles Froland, Mike Dorsey, and Dan Matthies, focuses more tightly on climate innovations, with the stated thesis of scaling top Stanford climate technologies to the industries they can decarbonize. The separation allows the firm to allocate dedicated capital to climate while maintaining a multi-sector early-stage vehicle.