Private Equity

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Ysios Capital Partners

Ysios Capital Partners, founded in 2008 by Joël Jean-Mairet and Julia Salaverría, is Spain's largest life-sciences VC with >€400M under management.

Ysios Capital Partners

Ysios Capital Partners

Founded in 2008 with offices in San Sebastián and Barcelona, Ysios Capital Partners assembled an international partnership of scientists and financiers including Joël Jean-Mairet, Julia Salaverría and Cristina Garmendia. The firm's improbable origin — building the Iberian peninsula's largest dedicated life-sciences venture platform from northern Spain, not Cambridge or Basel — shaped its thesis: source globally but commit to companies developing transformative therapeutics for indications with high unmet medical need. Ysios deploys exclusively into private biotech companies developing novel therapeutics and product-enabling platforms. Its portfolio spans antibody-drug conjugates (Adcendo, Denmark), regenerative cell therapies (Neurona Therapeutics, USA), bispecific antibody platforms (LAVA Therapeutics, NASDAQ: LVTX, Netherlands), gene therapy (SpliceBio, Spain; SparingVision, France) and small-molecule CNS programs (Synendos, Switzerland). The firm participates from seed through pre-IPO, often leading rounds and taking board seats — a posture confirmed by exits including Amgen's acquisition of BioVex, AstraZeneca's acquisition of Fusion Pharmaceuticals, and Takeda's acquisition of TiGenix (per firm disclosures, 2026). Geographic exposure concentrates on Europe and the United States, with portfolio companies headquartered in Spain, France, Switzerland, the Netherlands, Denmark and the US. Ysios manages over €400M across three global funds, most recently deploying through Ysios BioFund III with a concurrent €100M vehicle called InceptionBio aimed at company creation (per the firm, 2026). The partner roster — ten named operators — reflects a deliberate mix of operational, clinical and financial experience. In May 2026 the firm announced Synendos Therapeutics' progression to a Phase 2 trial in generalized anxiety disorder, marking the first time a Selective Endocannabinoid Reuptake Inhibitor (SERI) molecule reached a patient population. Unlike diversified venture platforms, Ysios imposes a hard therapeutic-mandate constraint: every portfolio company must advance a product candidate addressing an unmet medical need. This restriction means the firm cannot opportunistically chase software or consumer-health deals, creating a portfolio that correlates with FDA/EMA regulatory milestones rather than technology-adoption cycles. The structure forces a partnership model where firm principals sit on boards and work with academic founders to validate science before scaling, a governance approach that differentiates it from passive fund-of-funds allocators in biotech.

General information

Firm type

Private Equity

Year founded

2008

AUM

>€400M (per the firm, 2026)

Location

Region

Europe

Country

Spain

City

Donostia-San Sebastian

Corporate office

Donostia-San Sebastian, Spain

Additional offices

Barcelona, Spain

Principals

Joël Jean-Mairet

Partner

Julia Salaverría

Partner

Karen Wagner

Partner

Joan Perelló

Partner

Cristina Garmendia

Partner

Jordi Xiol

Partner

Guillem Laporta

Partner

Thomas Harth

Partner

Arturo Urrios

Partner

Iñigo López-Huerta

Partner

Sector focus

BiotechnologyDigital HealthTherapeuticsMedical DevicesDiagnostics

Frequently asked questions

Who runs investment decisions at Ysios Capital Partners?

The firm is led by a partnership of ten named principals including Joël Jean-Mairet, Julia Salaverría, Cristina Garmendia and Guillem Laporta (per the firm's team page, 2026). Investment decisions draw on a combination of scientific, financial and entrepreneurial expertise from this international group. The partnership structure suggests consensus-driven committee decisions rather than a single-operator model, though the firm does not publicly disclose its investment committee mechanics.

How does Ysios source proprietary biotech deal flow?

Ysios combines direct academic-institution relationships with a physical presence across two European offices — San Sebastián and Barcelona — to access early-stage therapeutic science. The firm's portfolio includes spin-outs from the Muir Lab at Princeton University (SpliceBio) and Leiden University Medical Center (VarmX), indicating it works directly with research institutions rather than relying on auction processes. Its 'InceptionBio' vehicle, launched in 2026, is explicitly designed for company creation, moving it even further upstream into IP origination.

Is Ysios structured as a family office or an institutional asset manager?

Ysios Capital Partners is an institutional asset manager operating as a venture capital firm, not a family office. It manages pooled third-party capital across multiple fund vehicles — currently deploying from Ysios BioFund III and the InceptionBio company-creation fund — and files as a regulated investment manager in Spain. The partnership structure and external capital base distinguish it from single-family investment offices.

Does Ysios participate in fund commitments or only direct deals?

Ysios invests directly into private biotech companies and does not operate as a fund-of-funds allocator. Its disclosures show equity positions in portfolio companies at the board level, with a consistent pattern of direct lead or co-lead investments. The firm has not disclosed any LP commitments to other venture funds; its model is direct therapeutic company-building.

What investment stages does Ysios typically target?

Ysios invests from seed through pre-IPO, with a concentration on early-stage and expansion-stage private biotech companies (per Altss research record, 2026). The firm's strategy includes spin-off vehicles and company creation via the InceptionBio fund, covering the earliest phases of therapeutic development. It maintains positions through later rounds, as evidenced by retained stakes in portfolio companies that subsequently listed on NASDAQ, including Aura Biosciences and Mineralys Therapeutics.

Which therapeutic areas does Ysios explicitly focus on?

The firm focuses exclusively on novel therapeutics for indications with high unmet medical need, spanning oncology (Adcendo, LAVA Therapeutics), CNS disorders (Synendos, Minoryx), cardiovascular conditions (CorWave, Mineralys Therapeutics), ophthalmology (SparingVision), metabolic disease (NorthSea Therapeutics) and reproductive medicine (ReproNovo). This therapeutic breadth within a single asset-class constraint — only drug and biologic developers — means Ysios operates as a sector-specialist rather than a platform generalist.

Where does Ysios Capital Partners' underlying capital come from?

Ysios does not publicly disclose the identity of its limited partners, so the underlying wealth source is not publicly known. The firm's investor base likely includes European institutional allocators, development banks and family offices, given its Spanish regulatory domicile and life-sciences mandate — but no specific LP names have been confirmed in public filings or the firm's own materials.

Profile maintained by using OSINT (open-source intelligence), regulatory filings, licensed data partners, and verified direct submissions. Read the methodology. Last updated: . Continuous refresh with full update cycles at least every 30 days.

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