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Zane Venture Fund
Shila Nieves Burney's Zane Venture Fund backs health-tech founders from an Atlanta base, with portfolio companies raising $40M in follow-on funding.
Zane Venture Fund
Zane Venture Fund was founded in Atlanta by Managing Partner Shila Nieves Burney, leveraging her two decades within national health organizations such as the American Cancer Society and the Black Women's Health Imperative. The firm's investment thesis draws directly from her personal health journey and institutional experience, targeting founders whose proximity to a clinical or patient problem gives them an edge in building for the healthcare economy. Zane invests at the earliest stages, from pre-revenue to roughly $500,000 in annual recurring revenue, backing B2B platforms that solve urgent problems for payers, employers, and health systems. Its portfolio spans digital health, enterprise software, and specialized SaaS, with confirmed positions including MDisrupt, an AI-powered healthtech expert marketplace that secured a $1M strategic investment from American Heart Association Ventures, and SimpliWorks, an e-commerce operations automation platform that doubled its paid user base while remaining capital-efficient. Geographically, the firm invests nationally from its Atlanta base, which it cites as having access to a regional market with 90 million people and 40 percent less venture competition. Team depth comes from both operational and investment experience. Managing Partner Sig Mosley, known in the Southeast as a prolific angel investor, co-manages the firm alongside his role at Mosley Ventures and carries a track record that includes the $5.7 billion exit of TradeX. A third Managing Director adds partnerships experience from Visa, Microsoft, Nike, and Salesforce Ventures. In August 2025, Zane is scheduled to host The Healthy Human Economy Innovation Exchange during Atlanta Tech Week, convening investors and health system leaders. Zane differentiates structurally through its Zane Access accelerator platform, which operates as a proprietary sourcing engine to identify founders before they reach broad market awareness. That platform, combined with a concentrated focus on the transition from reactive treatment to proactive prevention, creates a deal-flow architecture distinct from generalist venture funds.
General information
Firm type
Venture Capital
Year founded
—
AUM
Undisclosed
Location
Region
North America
Country
United States
City
Atlanta
Corporate office
Atlanta, GA, United States
Principals
Shila Nieves Burney
Managing Partner
Sig Mosley
Managing Partner (Mosley Ventures); previously described as "The Godfather of Angel Investing" in the Southeast
Rachel ...
Managing Director
Sector focus
Frequently asked questions
Who makes investment decisions at Zane Venture Fund?
Shila Nieves Burney leads investment decisions as Managing Partner. She brings 20 years of experience from national health organizations, including the American Cancer Society and Black Women's Health Imperative. The team also includes Sig Mosley, a recognized angel investor in the Southeast.
How does Zane source its deal flow?
The firm uses its proprietary Zane Access accelerator platform to identify founders with clinical or patient experience who are building B2B health platforms. This structure allows Zane to engage with companies before they reach broad market awareness, particularly in the Southeast where venture competition is lower.
Does Zane lead rounds or primarily follow?
Zane invests at the earliest stages, from pre-revenue to $500,000 ARR. The firm's numbers indicate that for every dollar it invested from Fund I, $24 followed from other investors, suggesting it often takes an initial position that is subsequently built upon by larger strategic and financial backers.
What kind of companies does Zane avoid?
Zane does not invest in direct-to-consumer health apps or wellness products without an enterprise B2B component. The firm focuses on platforms that serve payers, employers, and health systems, and explicitly targets the shift from reactive treatment to proactive prevention, avoiding companies that replicate existing fee-for-service models.
What is Zane Access and how does it relate to the fund?
Zane Access is the firm's proprietary accelerator platform, distinct from the venture fund but operating as its primary sourcing engine. It finds and develops founders with lived health experience, creating a pipeline of companies that the fund can then evaluate for investment.
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