Venture Capital

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ONSET Ventures

Onset Ventures is a venture capital firm that invests in information and medical technology-based start-ups. The firm has made 230 investments, including a...

ONSET Ventures logo

ONSET Ventures

Onset Ventures is a venture capital firm that invests in information and medical technology-based start-ups. The firm has made 230 investments, including a Series G investment in Vertos Medical on September 30, 2019. Onset Ventures has 60 portfolio exits, with Nok Nok Labs exiting on June 05, 2025.

General information

Firm type

Venture Capital

Year founded

1984

AUM

Undisclosed

Location

Region

North America

Country

United States

City

Menlo Park

Corporate office

Menlo Park, CA, United States

Principals

Terry Opdendyk

General Partner

Sector focus

Enterprise SoftwareDigital HealthAI/ML

Frequently asked questions

Who ran investment decisions at ONSET Ventures?

Terry Opdendyk served as the founding General Partner and led all investment decisions for over three decades. His background as an engineering manager at Hewlett-Packard informed the firm's highly technical due-diligence process. The partnership structure remained small, with Opdendyk as the central decision-maker throughout the firm's active life.

How did ONSET Ventures source proprietary deal flow?

ONSET sourced deal flow through its network of in-house engineers and entrepreneurs-in-residence, who actively scouted for technical founders and emerging technologies. The firm's deep ties to Stanford and the broader Silicon Valley engineering community provided access to companies before formal fundraising processes began. This technical-sourcing model was a deliberate alternative to relying on banker-led introductions.

What investment stages did ONSET Ventures typically target?

ONSET concentrated on the earliest stages: concept, seed, and startup phases where product-market fit was not yet established. The firm often wrote the first institutional check and continued supporting companies through early commercialization. It did not typically lead growth-stage rounds, preferring to engage when technical risk was the dominant variable.

Which sectors did ONSET Ventures explicitly avoid?

The firm avoided capital-intensive sectors such as semiconductors and clean-energy hardware, as well as consumer internet companies where technical differentiation was harder to sustain. ONSET's partnership believed its engineering-heavy model worked best in enterprise software and health-tech businesses with long R&D cycles. It also did not invest in life sciences therapeutics.

What was ONSET Ventures' known posture on co-investments alongside external GPs?

ONSET typically led or co-led seed rounds and maintained the option to invest significant engineering resources alongside its capital. The firm would syndicate with other early-stage specialists for follow-on rounds but preferred to have a board seat and active technical involvement in the companies it backed. This made pure passive co-investment uncommon.

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