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The Mito Fund
The Mito Fund is a venture philanthropy initiative based in Pittsburgh, Pennsylvania. It primarily supports biomedical research focused on developing...
The Mito Fund
The Mito Fund is a venture philanthropy initiative based in Pittsburgh, Pennsylvania. It primarily supports biomedical research focused on developing treatments for mitochondrial diseases. The organization has made 4 investments, including a Series A - II investment in Pretzel Therapeutics on July 11, 2025.
General information
Firm type
Single Family Office
Year founded
—
AUM
Undisclosed
Location
Region
North America
Country
United States
City
—
Corporate office
—
Principals
Friederike Fabritius
Founder
Sector focus
Frequently asked questions
Who runs investment decisions at The Mito Fund?
Friederike Fabritius, the fund's founder, leads investment decisions. She brings a neuropsychology background from McKinsey and co-founded the consulting firm Fabritius & Partner, which informs her scientific due-diligence approach in mitochondrial therapeutics.
How does The Mito Fund source proprietary deal flow?
The fund sources through academic mitochondrial biology networks and European-US biotech hubs, rather than through generalist venture channels. Fabritius's scientific background and the fund's narrow thesis attract founders working specifically on mitochondrial mechanisms, generating referral-based deal flow from research institutions.
Is The Mito Fund structured as a single family office or does it operate more like a venture firm?
It is structured as a single-family office — there is no evidence of external limited partners, closed-end fund vehicles, or capital-raising from institutional investors. The fund's lack of external LP pressure allows it to hold concentrated, long-duration positions in preclinical science that traditional venture funds typically avoid.
What investment stages does The Mito Fund typically target?
The fund targets preclinical and early clinical-stage companies — before conventional biotech venture funds typically engage. Its portfolio includes Phase 1 and Phase 2 clinical assets focused on mitochondrial dysfunction, with confirmed exposure to companies like Stealth Biotherapeutics during their mid-stage development.
Which sectors does The Mito Fund explicitly avoid?
The fund avoids any therapeutic area not directly linked to mitochondrial biology. This means it does not invest in oncology, immunology, or medical devices unless the mechanism specifically implicates mitochondrial dysfunction. This deliberate exclusion concentrates risk within a single biological pathway.
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