Updated:
H. Lee Moffitt Cancer Center & Research Institute
The H. Lee Moffitt Cancer Center & Research Institute, founded in 1986 through the Florida Legislature and named after former Florida House Speaker H.
H. Lee Moffitt Cancer Center & Research Institute
The H. Lee Moffitt Cancer Center & Research Institute, founded in 1986 through the Florida Legislature and named after former Florida House Speaker H. Lee Moffitt, operates as a non-profit dedicated to cancer care and research. Its main campus sits on the University of South Florida (USF) grounds in Tampa, reflecting a long-standing academic partnership. The institute is led by President and CEO Patrick Hwu, MD, with a board of directors chaired by Robert Rothman. Moffitt’s investment posture spans multiple asset classes — the center manages an endowment fund, owns commercial real estate across the Tampa Bay region (including the Moffitt Magnolia Campus, McKinley Campus, International Plaza, and Wesley Chapel locations), and holds undeveloped land in Pasco County, Florida. Through its relationship with Merck & Co. and the spinoff firm M2Gen/Aster Insights, Moffitt invests in digital health and AI/ML for personalized cancer medicine. The center is a member of the Alliance of Dedicated Cancer Centers, the National Comprehensive Cancer Network (NCCN), and YPO. Moffitt employs over 4,000 professionals across its clinical and research operations, with additional offices in Tampa’s International Plaza and Wesley Chapel. Board member Allison Casper Adams, a former YPO chapter chair, serves on the board. The center’s philanthropic arm is the H. Lee Moffitt Cancer Center & Research Institute Foundation, Inc., supporting research and patient programs. In May 2023, Moffitt broke ground on a new surgical oncology pavilion at its Magnolia Campus, expanding inpatient capacity (public record, 2023). Moffitt’s structural differentiator is its hybrid model as both a clinical enterprise and a research institute with an endowment — it generates revenue from patient care, then reinvests into biomedical R&D and real estate. Its spinoff M2Gen/Aster Insights, co-developed with Merck, positions it uniquely as an institutional investor in precision medicine infrastructure, not just a passive endowment.
General information
Firm type
Endowment / Foundation
Year founded
1986
AUM
Undisclosed
Location
Region
North America
Country
United States
City
Tampa
Corporate office
12902 USF Magnolia Drive, Tampa, FL, United States
Additional offices
10920 N. McKinley Drive, Tampa, FL, United States · 4225 Fleur de Lis Blvd, Tampa, FL, United States · 2590 Healing Way, Wesley Chapel, FL, United States · 12651 Telecom Dr, Temple Terrace, FL, United States
Principals
Patrick Hwu, MD
President and CEO
Robert Rothman
Chairman of the Board of Directors
Allison Casper Adams
Board Member
Sector focus
Frequently asked questions
Who runs investment decisions at H. Lee Moffitt Cancer Center?
Day-to-day operations are led by President and CEO Patrick Hwu, MD, with oversight from the board of directors chaired by Robert Rothman. The endowment fund is managed internally by the institute's finance team, but specifics on the investment committee are not publicly disclosed.
How does Moffitt invest its endowment?
Moffitt's endowment funds are deployed across a mix of asset classes including commercial real estate (e.g., Moffitt Magnolia Campus, McKinley Campus), undeveloped land in Pasco County, Florida, and equity stakes in biomedical spinoffs like M2Gen/Aster Insights. The center also participates in strategic partnerships with pharmaceutical companies such as Merck & Co.
Is Moffitt structured as a single-family office?
No. Moffitt is a non-profit cancer center and research institute with an endowment, not a family office. Its investment activities are part of its overall financial management, supporting clinical operations and research, with a philanthropic arm (the H. Lee Moffitt Cancer Center & Research Institute Foundation, Inc.).
What asset classes does Moffitt target in its real estate portfolio?
Moffitt's real estate holdings include medical office space (Moffitt at International Plaza, Wesley Chapel), a main hospital campus, and undeveloped land for future expansion (Speros FL in Pasco County). The center typically invests in properties that support its clinical and research missions.
How does Moffitt relate to the University of South Florida (USF)?
Moffitt is physically located on USF's Tampa campus and shares academic and research affiliations. The partnership includes joint faculty appointments, collaborative research initiatives, and shared biomedical infrastructure. Moffitt operates independently as a non-profit corporation under a board of directors.
Does Moffitt make direct venture capital investments?
Yes, primarily through its M2Gen/Aster Insights spinoff, which focuses on personalized medicine data analytics. The center also participates in strategic partnerships with life sciences firms like Merck, but does not operate a typical VC fund. Direct investments appear to be limited to biomedical and digital health ventures aligned with its mission.
What philanthropic structures does Moffitt maintain?
The H. Lee Moffitt Cancer Center & Research Institute Foundation, Inc. is the primary philanthropic vehicle, raising funds for research, patient care, and education. It is operationally separate from the clinical entity and focuses on donor contributions and grant-making.
Profile maintained by Altss using OSINT (open-source intelligence), regulatory filings, licensed data partners, and verified direct submissions. Read the methodology. Last updated: . Continuous refresh with full update cycles at least every 30 days.
Need institutional-grade insight on endowments & foundations?
Altss delivers:
Prefer a guided tour?
We’ll walk you through: