WPSS.bio

WPSS.bio

Founded by Managing Partners Sonia Weiss Pick and Daniel Weiss Pick, WPSS.bio operates from New York as a dedicated mental-health venture firm. The group deploys capital into early-stage companies developing diagnostics and therapeutics for psychiatric and neurological conditions — a niche that historically saw limited venture interest until the recent psychedelic-medicine revival and regulatory shifts around depression treatments. WPSS.bio structures its portfolio across seed and startup-stage equity, targeting breakthroughs in psychedelic medicine, precision psychiatry, and brain-computer interfaces. Confirmed positions include Alto Neuroscience, Blackrock Neurotech, and Delix Therapeutics, the latter of which raised $70 million for non-hallucinogenic psychedelic analogs (per the firm, 2024). The firm sources globally but concentrates execution in the United States, drawing on an advising team with deep affiliations at Massachusetts General Hospital and Harvard Medical School — including Psychiatrist-in-Chief Emeritus Jerry Rosenbaum and radiochemistry director Jacob Hooker. The firm reports four early-stage-backed IPOs and a 15.2x multiple on invested capital, though precise AUM and fund-vintage details remain undisclosed. Beyond the core portfolio, the founders have made off-thesis investments in adjacent health-technology startups and support underfunded scientific research through direct contributions. No separate philanthropic foundation is listed, but the firm publicly names causes and radical-research teams it backs alongside its venture activity. WPSS.bio’s structural differentiator is its embedded-science model: rather than relying solely on GP networks for deal flow, the firm maintains an active advising bench of Harvard Medical School faculty and domain-specific CEOs to evaluate deeply technical — often federally regulated — brain-health technologies. This turns conventional biotech venture sourcing on its head, making the fund resemble a translational-research collaborator more than a passive check-writer.