Upsher Management Company

Upsher Management Company

Upsher Management Company was established in 1969 following the Lubin family's exit from Desitin Pharmaceutical. The office remains headquartered in New York with an additional presence in Jackson, Wyoming. Its investment activity continues the family's century-long focus on health and life sciences while expanding into new themes. The firm deploys capital through early-stage venture, growth equity, core private equity, and public-market holdings. Portfolio holdings include ACV Auctions, Rivian, Dataminr, and Capella Space. Investments span North America, Europe, Asia, the Middle East, Africa, and South America. The office also participates in direct co-investments, SPVs, hedge funds, private credit, real estate, and natural resources. Upsher reports more than 100 active investments segmented into geopolitical investing, health and life sciences, and the broader technology ecosystem. Additional offices support operations in Wyoming. No dated operational events from the last 24 months appear in public materials. The office structures its mandate around decade-long thematic research cycles that sit alongside the legacy healthcare book. Geopolitical turbulence has been treated as an explicit allocation theme since 2020, directing capital toward sectors where internal insight connects policy shifts to investment outcomes.